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Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.
Misheva M, Kotzamanis K, Davies LC, Tyrrell VJ, Rodrigues PRS, Benavides GA, Hinz C, Murphy RC, Kennedy P, Taylor PR, Rosas M, Jones SA, McLaren JE, Deshpande S, Andrews R, Schebb NH, Czubala MA, Gurney M, Aldrovandi M, Meckelmann SW, Ghazal P, Darley-Usmar V, White DA, O'Donnell VB. Misheva M, et al. Among authors: tyrrell vj. Nat Commun. 2022 Jan 10;13(1):139. doi: 10.1038/s41467-021-27766-8. Nat Commun. 2022. PMID: 35013270 Free PMC article.
Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements.
Millrine D, Cardus Figueras A, Uceda Fernandez J, Andrews R, Szomolay B, Cossins BC, Rice CM, Li J, Tyrrell VJ, McLeod L, Holmans P, O'Donnell VB, Taylor PR, Turner SJ, Jenkins BJ, Jones GW, Topley N, Williams NM, Jones SA. Millrine D, et al. Among authors: tyrrell vj. J Immunol. 2023 Jul 15;211(2):274-286. doi: 10.4049/jimmunol.2300114. J Immunol. 2023. PMID: 37272871 Free PMC article.
Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis.
Gallagher H, Williams JO, Ferekidis N, Ismail A, Chan YH, Michael DR, Guschina IA, Tyrrell VJ, O'Donnell VB, Harwood JL, Khozin-Goldberg I, Boussiba S, Ramji DP. Gallagher H, et al. Among authors: tyrrell vj. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2538-2550. doi: 10.1016/j.bbadis.2019.06.011. Epub 2019 Jun 13. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31202985 Free PMC article.
Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.
Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB. Slatter DA, et al. Among authors: tyrrell vj. JCI Insight. 2018 Mar 22;3(6):e98459. doi: 10.1172/jci.insight.98459. JCI Insight. 2018. PMID: 29563336 Free PMC article.
The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses.
Saud Z, Tyrrell VJ, Zaragkoulias A, Protty MB, Statkute E, Rubina A, Bentley K, White DA, Rodrigues PDS, Murphy RC, Köfeler H, Griffiths WJ, Alvarez-Jarreta J, Brown RW, Newcombe RG, Heyman J, Pritchard M, Mcleod RW, Arya A, Lynch CA, Owens D, Jenkins PV, Buurma NJ, O'Donnell VB, Thomas DW, Stanton RJ. Saud Z, et al. Among authors: tyrrell vj. J Lipid Res. 2022 Jun;63(6):100208. doi: 10.1016/j.jlr.2022.100208. Epub 2022 Apr 15. J Lipid Res. 2022. PMID: 35436499 Free PMC article.
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